Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059769 | 0.90 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059181 | 0.89 | LRRK2 (0.46) | LRRK2PRKCQ | |
| SCHEMBL14059307 | 0.85 | LRRK2 (0.66) | LRRK2 | |
| SCHEMBL14059209 | 0.84 | LRRK2 (0.64) | LRRK2AAK1GSK3BPRKACACDK8 | |
| SCHEMBL14060226 | 0.82 | LRRK2 (0.44) | LRRK2CLK4 | |
| SCHEMBL14060221 | 0.82 | LRRK2 (0.65) | LRRK2AAK1GSK3BPRKACACDK8 | |
| SCHEMBL14059259 | 0.82 | LRRK2 (0.46) | LRRK2PRKCQ | |
| SCHEMBL14059316 | 0.81 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL14059866 | 0.81 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL14059532 | 0.81 | LRRK2 (0.44) | LRRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |