Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 7/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059647 | 0.90 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059181 | 0.90 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059259 | 0.87 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059133 | 0.85 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL14059477 | 0.85 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059793 | 0.83 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL14059025 | 0.83 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL14060226 | 0.83 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL14059470 | 0.83 | FYN (0.42) | LRRK2 | |
| SCHEMBL14059866 | 0.82 | LRRK2 (0.48) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |