Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 11/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406059 | 0.85 | PTGDR2 (0.71) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406035 | 0.85 | PTGDR2 (0.65) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406100 | 0.83 | PTGDR2 (0.62) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1405973 | 0.83 | PTGDR2 (0.62) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406010 | 0.79 | PTGDR2 (0.73) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406178 | 0.77 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406113 | 0.74 | PTGDR2 (0.77) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL4280028 | 0.73 | PTGDR2 (0.53) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406169 | 0.70 | PTGDR2 (0.76) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL13953013 | 0.68 | PTGDR2 (0.64) | PTGDR2AKR1B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513812-B1 | SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | claimed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | claimed |
| US-20050165055-A1 | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-07-28 | — | — | US | claimed |
| EP-1513812-A1 | SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2005-03-16 | — | — | EP | claimed |
| WO-2003101961-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | claimed |
| EP-1513812-B1 | SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1513812-B1 | SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-20050165055-A1 | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-07-28 | — | — | US | disclosed |
| EP-1513812-A1 | SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101961-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165055-A1 | Novel substituted indoles | IDO1, IDO2, TPH1 | PTGDR2 426/4885AKR1B1 302/4885CYP2C9 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.