Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14062308 | 0.94 | LRRK2 (0.55) | LRRK2BRD9PDE5A | |
| SCHEMBL14060226 | 0.88 | LRRK2 (0.44) | LRRK2USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14059530 | 0.86 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL14059470 | 0.86 | FYN (0.42) | LRRK2CYP3A4 | |
| SCHEMBL14059413 | 0.84 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL17135922 | 0.83 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL14059383 | 0.83 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL14059477 | 0.83 | LRRK2 (0.46) | LRRK2USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14059118 | 0.81 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL14059572 | 0.80 | LRRK2 (0.49) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |