Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Ethylbenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.88 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylbenzene SCHEMBL29 | 0.94 | — | — | |
| Ethylbenzene SCHEMBL27454352 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 | |
| Ethylbenzene SCHEMBL3987542 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 | |
| Ethylbenzene SCHEMBL1330604 | 0.94 | — | — | |
| Ethylbenzene SCHEMBL1332452 | 0.94 | — | — | |
| Ethylbenzene SCHEMBL27395806 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 | |
| Ethylbenzene SCHEMBL1331299 | 0.94 | — | — | |
| Ethylbenzene SCHEMBL7458207 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 | |
| Ethylbenzene SCHEMBL11223212 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 | |
| Ethylbenzene SCHEMBL2308215 | 0.94 | TP53 (1.00) | TP53CALM1ALDH1A1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390767-A | Preparation method of eperisone hydrochloride impurity F | 嘉实（湖南）医药科技有限公司 | 2021-02-23 | — | — | CN | claimed |
| CN-108373407-A | Fluorine-containing epoxy oligomer base ethylbenzene and preparation method thereof | 陕西师范大学 | 2018-08-07 | — | — | CN | claimed |
| CN-113559923-B | VOx/Zr-TUD-1 catalyst and method for preparing fluorine-containing epoxy oligomer-based styrene by catalytic dehydrogenation | 陕西师范大学 | 2023-08-29 | — | — | CN | disclosed |
| CN-112390767-A | Preparation method of eperisone hydrochloride impurity F | 嘉实（湖南）医药科技有限公司 | 2021-02-23 | — | — | CN | disclosed |
| CN-108373407-A | Fluorine-containing epoxy oligomer base ethylbenzene and preparation method thereof | 陕西师范大学 | 2018-08-07 | — | — | CN | disclosed |
| EP-2712359-B1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-21 | — | — | EP | disclosed |
| US-9522931-B2 | Process for the preparation of compounds useful as inhibitors of SGLT-2 | JANSSEN PHARMACEUTICA NV (BE) | 2016-12-20 | — | — | US | disclosed |
| US-20140206858-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-24 | — | — | US | disclosed |
| WO-2012162115-A2 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206858-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 | SLC5A2, SLC5A1, SI | TP53 4862/4885CALM1 4644/4885ALDH1A1 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.