Sugi Predict

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SI

Sucrase-isomaltase, intestinal · P14410 · SI on Sugi Atlas →

71,004 patent compounds predicted against SI, 38,373 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Voglibose Voglibose (SCHEMBL5882) 0.61 17/20
SCHEMBL110724 SCHEMBL110724 0.53 15/20
SCHEMBL159015 SCHEMBL159015 0.52 15/20
SCHEMBL170673 SCHEMBL170673 0.71 9/20
SCHEMBL202954 SCHEMBL202954 0.54 9/20
SCHEMBL124191 SCHEMBL124191 0.59 7/20
SCHEMBL108954 SCHEMBL108954 0.57 7/20
SCHEMBL45441 SCHEMBL45441 0.64 6/20
SCHEMBL37609 SCHEMBL37609 0.48 6/20
SCHEMBL230979 SCHEMBL230979 0.48 6/20
SCHEMBL37608 SCHEMBL37608 0.47 6/20
SCHEMBL37629 SCHEMBL37629 0.45 6/20
Acarbose Acarbose (SCHEMBL16848) 1.00 5/20
Acarbose Acarbose (SCHEMBL16849) 1.00 5/20
SCHEMBL94134 SCHEMBL94134 0.60 5/20
Validamycin A Validamycin A (SCHEMBL22760) 0.56 5/20
Validamycin A Validamycin A (SCHEMBL22761) 0.56 5/20
SCHEMBL204056 SCHEMBL204056 0.54 5/20
SCHEMBL240665 SCHEMBL240665 0.54 5/20
SCHEMBL148211 SCHEMBL148211 0.52 5/20

Clinical trials — most relevant to SI by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin PHASE4UNKNOWN
Efficacy of Acarbose on Intestinal Microbiome and Incretins of Type 2 Diabetes PHASE4UNKNOWN
The Effect Tenofovir Disoproxil Fumarate (TDF) and Tenofovir Alafenamide (TAF) on Small Intestine Gut Wall PHASE4UNKNOWN
Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS) PHASE4COMPLETED
Metabolic Effects of Non-Nutritive Sweeteners PHASE1/PHASE2COMPLETED
Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference PHASE2COMPLETED
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes PHASE2RECRUITING
Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
The Effects of L-arabinose on Intestinal Sucrase Activity in Man PHASE1COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans PHASE1COMPLETED
Carbohydrates and Gut Hormones After Gastric Bypass Surgery nanCOMPLETED
Sucrase-Isomaltase (SI) Genes and Meal Load nanRECRUITING
Evaluation of Gastrointestinal Symptoms Following Chilean Native Beans Consumption nanUNKNOWN
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Delineation of the Role of Glucagon-like Peptide-1 Signalling in Relation to Increased Carbohydrate Content in the Distal Small Intestines nanCOMPLETED
Extra Virgin Olive Oil on Glycemic Control ,Insulin Resistance and Insulin Secretion nanUNKNOWN
The Effect of Sugar Load in IBS Patients Depending on Sucrase-isomaltase Genes nanCOMPLETED
Cellodextrin Tolerability Study nanCOMPLETED
Sucrase-isomaltase Deficiency as a Cause of Irritable Bowel Syndrome nanNOT_YET_RECRUITING
Prospective Study in Pelvic Radiotherapy Patients nanCOMPLETED
Algal Lutein Against Decline of Intellectual Nimbleness nanNOT_YET_RECRUITING
The Effects of L-arabinose in a Meal in Healthy Men nanCOMPLETED
Efficacy of Fructose Metabolizing Enzymatic Product in Fructose Malabsorption nanCOMPLETED
Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance? nanCOMPLETED
Effects of Green Banana BIOmass Consumption in Patients With Pre-diabetes and Diabetes MELlitus (The BIOMEL Study) nanUNKNOWN
A Study to Determine the Safety and Efficacy of Oligopin® on Metabolic Risk Factors in Subjects With Metabolic Syndrome nanUNKNOWN
Effects of TCM on Beta-cell Function and Insulin Resistance in High Risk Chinese Individuals for T2D (TCM_PDiab_P01) nanUNKNOWN
Secondary Lactose Intolerance Due to Chronic Norovirus Infection nanCOMPLETED
Microbial Enzyme Impact on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Adults nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SI binder may also engage these)

ProteinNameSimilarity
MGAM Maltase-glucoamylase 1.000 landscape →
P23739 — 1.000 P23739 →
MGAM2 Probable maltase-glucoamylase 2 (Maltase-gluc 1.000 landscape →
O62653 — 1.000 O62653 →
P07768 — 0.997 P07768 →
Q92442 — 0.994 Q92442 →
F4J6T7 — 0.993 F4J6T7 →
O04931 — 0.993 O04931 →
P38138 — 0.990 P38138 →
Q9S7Y7 — 0.989 Q9S7Y7 →
Q9US55 — 0.989 Q9US55 →
Q93324 — 0.989 Q93324 →
P15684 — 0.988 P15684 →
P79098 — 0.988 P79098 →
P07190 — 0.987 P07190 →
Q9VTJ4 — 0.987 Q9VTJ4 →
P97449 — 0.987 P97449 →
P29064 — 0.987 P29064 →
P34098 — 0.986 P34098 →
Q9C0Y4 — 0.986 Q9C0Y4 →
Q86M34 — 0.986 Q86M34 →
P28843 — 0.986 P28843 →
O00906 — 0.986 O00906 →
Q95WY5 — 0.986 Q95WY5 →
Q09901 — 0.985 Q09901 →
P79171 — 0.985 P79171 →
ANPEP Aminopeptidase N 0.985 landscape →
B0XAA1 — 0.984 B0XAA1 →
P15541 — 0.984 P15541 →
Q9GV16 — 0.984 Q9GV16 →