SCHEMBL1406079

SCHEMBL1406079

CC(=O)O/N=C(/C(=O)O)c1csc(N)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.47
LMNA P02545 2/20 0.47
GAA P10253 1/20 0.47
MEN1 O00255 2/20 0.46
ALDH1A1 P00352 2/20 0.46
KMT2A Q03164 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
USP2 O75604 1/20 0.39
ESR1 P03372 1/20 0.39
KDM4E B2RXH2 1/20 0.39
NR1I2 O75469 2/20 0.38
PGR P06401 1/20 0.38
PTGS2 P35354 1/20 0.38
ALB P02768 1/20 0.38
PPARG P37231 1/20 0.38
SLC22A6 Q4U2R8 1/20 0.38
SLC22A8 Q8TCC7 1/20 0.38
SLC22A11 Q9NSA0 1/20 0.38
GABRA5 P31644 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5847024 1.00 MAPT (0.47) MAPTLMNAGAAMEN1ALDH1A1
SCHEMBL1406081 1.00 MAPT (0.47) MAPTLMNAGAAMEN1ALDH1A1
Water SCHEMBL5174358 0.99 MAPT (0.46) MAPTLMNAGAAMEN1ALDH1A1
Hydrochloric Acid SCHEMBL5099552 0.99 MAPT (0.48) MAPTLMNAGAAMEN1ALDH1A1
Water SCHEMBL7801345 0.99 MAPT (0.46) MAPTLMNAGAAMEN1ALDH1A1
Water SCHEMBL5174360 0.99 MAPT (0.46) MAPTLMNAGAAMEN1ALDH1A1
Water SCHEMBL5176169 0.99 MAPT (0.46) MAPTLMNAGAAMEN1ALDH1A1
Hydrochloric Acid SCHEMBL27712434 0.99 MAPT (0.48) MAPTLMNAGAAMEN1ALDH1A1
Water SCHEMBL5176172 0.99 MAPT (0.46) MAPTLMNAGAAMEN1ALDH1A1
Hydrochloric Acid SCHEMBL7810063 0.99 MAPT (0.48) MAPTLMNAGAAMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080081906-A1 CEFDINIR INTERMEDIATE KREMMINGER PETER 2008-04-03 US claimed
US-20060025586-A1 Cefdinir intermediate SANDOZ AG (CH) 2006-02-02 US claimed
EP-1554289-A1 A CEFDINIR INTERMEDIATE Sandoz AG (CH) 2005-07-20 EP claimed
WO-2004016623-A1 A CEFDINIR INTERMEDIATE SANDOZ AG (CH) 2004-02-26 WO claimed
JP-8041041-A None JP disclosed
JP-8041041-A None JP disclosed
EP-1554289-B1 A CEFDINIR INTERMEDIATE SANDOZ AG (CH) 2011-03-09 EP disclosed
US-7825241-B2 Cefdinir intermediate SANDOZ AG (CH) 2010-11-02 US disclosed
US-20080081906-A1 CEFDINIR INTERMEDIATE KREMMINGER PETER 2008-04-03 US disclosed
EP-1842852-A1 A CEFDINIR INTERMEDIATE Sandoz AG (CH) 2007-10-10 EP disclosed
US-7250508-B2 Cefdinir intermediate SANDOZ AG (CH) 2007-07-31 US disclosed
EP-1786793-A1 TERTIARY AMINE SALTS OF 2-(2-AMINOTHIAZOLE-4-YL)-2-(ACYLOXYIMINO)ACETIC ACID Sandoz AG (CH) 2007-05-23 EP disclosed
EP-1340751-A1 PROCESS FOR PRODUCING ANHYDRIDE OF AMINOTHIAZOLE DERIVATIVE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-09-03 EP disclosed
JP-H0841041-A METHOD FOR PRODUCING 2-(2-AMINOTHIAZOL-4-YL)-2-ACETOXYIMINOACETIC ACID OR ITS DERIVATIVE TOKUYAMA CORP 1996-02-13 JP disclosed
JP-H0841041-A METHOD FOR PRODUCING 2-(2-AMINOTHIAZOL-4-YL)-2-ACETOXYIMINOACETIC ACID OR ITS DERIVATIVE TOKUYAMA CORP 1996-02-13 JP disclosed
EP-0185221-B1 PROCESS FOR THE PREPARATION OF AMINOTHIAZOLYLACETIC-ACID DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1990-09-26 EP disclosed
US-4888429-A Process for producing allyl aminothiazole acetate intermediates HOFFMANN-LA ROCHE INC. (US) 1989-12-19 US disclosed
EP-0214462-A2 3,7-Disubstituted-3-cephem compounds and processes for production of the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1987-03-18 EP disclosed
EP-0185220-A2 Intermediates for the preparation of cephalosporins F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1986-06-25 EP disclosed
EP-0185221-A2 Process for the preparation of aminothiazolylacetic-acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1986-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025586-A1 Cefdinir intermediate PCMT1, SULT1E1, AASDHPPT MAPT 2935/4885LMNA 4843/4885GAA 4356/4885
US-20080081906-A1 CEFDINIR INTERMEDIATE PCMT1, AASDHPPT, SULT1E1 MAPT 2866/4885LMNA 4844/4885GAA 3846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.