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Sugi Predict / Compounds / SCHEMBL1406111

SCHEMBL1406111

SCHEMBL1406111

[2H]c1c(C(=O)NC2CC2)ccc(C)c1-c1ccc2c(OC(C)C(F)(F)F)nncc2c1

nearest known ligand 0.88

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 16/20 0.88
▸ KIT P10721 10/20 0.88
▸ KDR P35968 9/20 0.88
▸ MAPK9 P45984 6/20 0.88
▸ LCK P06239 6/20 0.88
▸ MAPK10 P53779 2/20 0.88
▸ LYN P07948 1/20 0.88
▸ CSF1R P07333 1/20 0.45
▸ MAPK13 O15264 3/20 0.42
▸ RIPK2 O43353 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL395871 0.93 MAPK14 (1.00) MAPK14KITKDRMAPK9LCK
SCHEMBL393435 0.93 MAPK14 (1.00) MAPK14KITKDRMAPK9LCK
SCHEMBL395967 0.93 MAPK14 (1.00) MAPK14KITKDRMAPK9LCK
SCHEMBL10203411 0.88 MAPK14 (0.89) MAPK14KITKDRMAPK9LCK
SCHEMBL394731 0.85 MAPK14 (0.79) MAPK14KITKDRMAPK9LCK
SCHEMBL392556 0.85 MAPK14 (0.79) MAPK14KITKDRMAPK9LCK
SCHEMBL2955025 0.84 MAPK14 (1.00) MAPK14KITKDRMAPK9LCK
SCHEMBL1406123 0.82 MAPK14 (0.77) MAPK14KITKDRMAPK9LCK
SCHEMBL1406009 0.82 MAPK14 (0.77) MAPK14KITKDRMAPK9LCK
SCHEMBL397175 0.82 MAPK14 (0.79) MAPK14KITKDRMAPK9LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2077998-B1 PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE AMGEN INC (US) 2011-03-09 — — EP disclosed