Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.54 |
| ▸ | HTR1A | P08908 | 12/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | FPR3 | P25089 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406042 | 0.94 | HTR1A (0.57) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1323768 | 0.90 | SLC6A2 (0.65) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1406205 | 0.84 | HTR1A (0.53) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1323756 | 0.83 | HTR1A (0.70) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL5736429 | 0.83 | HTR1A (0.63) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL12124063 | 0.78 | SLC6A2 (0.64) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1323840 | 0.78 | HTR1A (0.56) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1323787 | 0.77 | HTR1A (0.53) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL1323806 | 0.76 | HTR1A (0.54) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A | |
| SCHEMBL12121308 | 0.76 | HTR1A (0.52) | SLC6A2SLC6A3HTR1ASLC6A4ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| JP-2005523310-A | — | — | 2005-08-04 | — | — | JP | claimed |
| US-6911476-B2 | Sulfonamide derivatives | ELI LILLY AND COMPANY (US) | 2005-06-28 | — | — | US | claimed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | claimed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | claimed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |