Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.50 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | TYK2 | P29597 | 4/20 | 0.48 |
| ▸ | PLK4 | O00444 | 3/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | MARK3 | P27448 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276223 | 0.89 | PDPK1 (0.65) | JAK2PDPK1JAK3AURKBCDK2 | |
| SCHEMBL14063558 | 0.84 | JAK2 (0.42) | JAK2PDPK1DYRK1AMAPK1GSK3B | |
| SCHEMBL14072480 | 0.81 | JAK2 (0.67) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL26886503 | 0.80 | PDPK1 (0.74) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL26686262 | 0.80 | JAK2 (0.57) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL10213929 | 0.79 | JAK2 (0.81) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL31420172 | 0.79 | JAK2 (0.50) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL26686034 | 0.79 | JAK2 (0.50) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL26686037 | 0.79 | JAK2 (0.50) | JAK2PDPK1JAK3AURKBTYK2 | |
| SCHEMBL31240651 | 0.78 | JAK2 (0.67) | JAK2PDPK1JAK3AURKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |