Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 8/20 | 0.47 |
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | IKBKB | O14920 | 4/20 | 0.44 |
| ▸ | CHUK | O15111 | 3/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063778 | 0.91 | JAK2 (0.51) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL4063691 | 0.89 | JAK2 (0.52) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL14021306 | 0.88 | SYK (0.54) | CDC7CDK19JAK2JAK3IKBKB | |
| SCHEMBL14021327 | 0.87 | JAK2 (0.49) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL14021298 | 0.87 | SYK (0.52) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL14063777 | 0.87 | JAK2 (0.49) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL13590765 | 0.85 | JAK2 (0.51) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL14021233 | 0.85 | CDK1 (0.49) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL14063849 | 0.85 | PIK3CA (0.48) | CDC7CDK19JAK2JAK3IKBKB | |
| SCHEMBL4392408 | 0.84 | PIK3CA (0.51) | JAK2JAK3IKBKBCHUKIKBKG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |