Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065176 | 0.83 | UTS2R (0.84) | UTS2RCYP19A1PPARGPPARA | |
| SCHEMBL14064826 | 0.81 | UTS2R (0.66) | UTS2RCYP19A1PPARGPPARACYP1A2 | |
| SCHEMBL3277857 | 0.80 | SLC6A4 (0.59) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14065228 | 0.80 | UTS2R (0.68) | UTS2RCYP19A1PPARGPPARA | |
| SCHEMBL14064819 | 0.79 | SLC6A4 (0.58) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21118559 | 0.78 | TP53 (0.57) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8077913 | 0.76 | PPARG (0.53) | UTS2RCYP19A1PPARGPPARAKMT2A | |
| SCHEMBL27999195 | 0.76 | CYP19A1 (0.61) | UTS2RCYP19A1PPARGPPARACYP3A4 | |
| SCHEMBL20917307 | 0.76 | SLC6A4 (0.59) | SLC6A4SLC6A2KMT2A | |
| SCHEMBL5455926 | 0.75 | UTS2R (1.00) | UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1964561-A1 | Inhibitors of IMPDH enzyme | Vertex Pharmaceuticals Incorporated (US) | 2008-09-03 | — | — | EP | disclosed |