Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066132 | 0.90 | PTGES (0.51) | PTGESALOX5LPAR1LPAR5MEP1B | |
| SCHEMBL4650121 | 0.79 | STAT3 (0.51) | PTGESALOX5LPAR1LPAR5MEP1B | |
| Hydrochloric Acid SCHEMBL4929857 | 0.79 | STAT3 (0.50) | PTGESALOX5LPAR1LPAR5MEP1B | |
| SCHEMBL14270629 | 0.78 | FFAR1 (0.55) | PTGESALOX5LPAR1LPAR5NR4A2 | |
| SCHEMBL13009771 | 0.77 | PTGER1 (0.48) | ALOX5MEN1KMT2AMAPK14LPAR1 | |
| SCHEMBL14270650 | 0.75 | FFAR4 (0.47) | FFAR1FFAR4 | |
| SCHEMBL13009856 | 0.74 | PTGER1 (0.49) | ALOX5MRGPRX4FFAR1FFAR4PPARD | |
| SCHEMBL4650017 | 0.74 | PPARD (0.41) | PTGESALOX5MEN1KMT2ALPAR1 | |
| SCHEMBL13378384 | 0.74 | PPARD (0.46) | NR4A2FFAR1FFAR4PPARGPPARD | |
| SCHEMBL10811351 | 0.73 | FFAR1 (0.53) | FFAR1FFAR4PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368302-B1 | NOVEL AMINO DICARBOXYLIC ACID DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| US-7329777-B2 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis | BAYER AKTIENGESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |
| US-7329777-B2 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis | BAYER AKTIENGESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |