Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.75 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.74 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.55 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.55 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347954 | 0.96 | TP53 (0.70) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL14066700 | 0.88 | TP53 (0.60) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL4651590 | 0.86 | TP53 (1.00) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL4651385 | 0.86 | BCL2L1 (0.98) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL12665331 | 0.83 | TP53 (0.56) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL4652556 | 0.83 | BCL2L1 (0.79) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL14066642 | 0.80 | TP53 (0.53) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL14347691 | 0.80 | BCL2L1 (0.71) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL14066663 | 0.79 | TP53 (0.54) | TP53MDM2BCL2L1MCL1BCL2L11 | |
| SCHEMBL14066635 | 0.78 | TP53 (0.53) | TP53MDM2BCL2L1MCL1BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408986-B1 | PROTEOMIMETIC COMPOUNDS AND METHODS | UNIV YALE (US) | 2008-09-24 | — | — | EP | disclosed |