Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066685 | 0.91 | TP53 (0.51) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL4651407 | 0.86 | BCL2L1 (0.76) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14347478 | 0.84 | BCL2L1 (0.68) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066645 | 0.83 | TP53 (0.75) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14347954 | 0.80 | TP53 (0.70) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066551 | 0.79 | TP53 (0.37) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL13343696 | 0.77 | TP53 (0.48) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066558 | 0.73 | PDE1A (0.65) | TP53MDM2BCL2L1MCL1FFAR1 | |
| SCHEMBL14347691 | 0.73 | BCL2L1 (0.71) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL5340223 | 0.72 | GABRA1 (0.46) | TP53MDM2BCL2L1MCL1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288335-B2 | ApoE analogs and methods for their use | Cognosei, Inc. (US) | 2012-10-16 | — | — | US | disclosed |
| US-7947645-B2 | APO E analogs and methods for their use | COGNOSCI, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090042783-A1 | APO E ANALOGS AND METHODS FOR THEIR USE | CORNERSTONE BIOSCIENCES, INC. | 2009-02-12 | — | — | US | disclosed |
| EP-1408986-B1 | PROTEOMIMETIC COMPOUNDS AND METHODS | UNIV YALE (US) | 2008-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042783-A1 | APO E ANALOGS AND METHODS FOR THEIR USE | APOB, APOL1, APP | TP53 3815/4885MDM2 3672/4885BCL2L1 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.