Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28107006 | 0.82 | NPC1 (0.42) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL6043112 | 0.80 | CYP1A2 (0.44) | RAB9ANPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1935423 | 0.80 | RAB9A (0.41) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL423984 | 0.78 | RAB9A (0.40) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL1700940 | 0.78 | KMT2A (0.40) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL12321755 | 0.78 | EPHX1 (0.44) | RAB9ANPC1KMT2AALDH1A1MAPT | |
| SCHEMBL1422981 | 0.78 | KMT2A (0.40) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL14000542 | 0.77 | RAB9A (0.39) | RAB9ANPC1KMT2ALMNAKDM4E | |
| SCHEMBL13041496 | 0.75 | SMN1; SMN2 (0.61) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10305114 | 0.75 | EPHX2 (0.49) | NPC1LMNAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | RAB9A 3176/4885NPC1 4153/4885KMT2A 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.