Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.81 |
| ▸ | ABL1 | P00519 | 6/20 | 0.72 |
| ▸ | SRC | P12931 | 5/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.72 |
| ▸ | EGFR | P00533 | 3/20 | 0.72 |
| ▸ | FYN | P06241 | 3/20 | 0.72 |
| ▸ | YES1 | P07947 | 3/20 | 0.72 |
| ▸ | LYN | P07948 | 3/20 | 0.72 |
| ▸ | HCK | P08631 | 3/20 | 0.72 |
| ▸ | KIT | P10721 | 3/20 | 0.72 |
| ▸ | BCR | P11274 | 3/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.72 |
| ▸ | FGR | P09769 | 2/20 | 0.72 |
| ▸ | JAK3 | P52333 | 2/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.72 |
| ▸ | SIK1 | P57059 | 2/20 | 0.63 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.63 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147099 | 0.95 | LCK (0.77) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL1146784 | 0.94 | LCK (0.77) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL1146749 | 0.94 | LCK (0.77) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL8213695 | 0.90 | LCK (0.81) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL31634947 | 0.90 | LCK (1.00) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL25737565 | 0.90 | LCK (0.87) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL773124 | 0.90 | LCK (1.00) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL14067011 | 0.89 | LCK (0.74) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL31017686 | 0.89 | LCK (0.85) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL1147077 | 0.89 | LCK (0.85) | LCKABL1SRCMAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | LCK 969/4885ABL1 1691/4885SRC 901/4885 |
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | LCK, ABL1, SRC | LCK 1/4885ABL1 2/4885SRC 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.