Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.82 |
| ▸ | CDK9 | P50750 | 11/20 | 0.82 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.82 |
| ▸ | CDK1 | P06493 | 4/20 | 0.82 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.82 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.82 |
| ▸ | CDK7 | P50613 | 3/20 | 0.82 |
| ▸ | CCNH | P51946 | 3/20 | 0.82 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.82 |
| ▸ | CDK4 | P11802 | 3/20 | 0.82 |
| ▸ | CCND1 | P24385 | 3/20 | 0.82 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.82 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.82 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.82 |
| ▸ | CCND2 | P30279 | 2/20 | 0.82 |
| ▸ | CCND3 | P30281 | 2/20 | 0.82 |
| ▸ | CIT | O14578 | 1/20 | 0.82 |
| ▸ | CASK | O14936 | 1/20 | 0.82 |
| ▸ | AURKA | O14965 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14093617 | 0.91 | CDK2 (0.84) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4731669 | 0.90 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| Bms-387032 SCHEMBL187401 | 0.90 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4735461 | 0.90 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4999468 | 0.90 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4733685 | 0.89 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4730239 | 0.89 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL4731289 | 0.89 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 | |
| Bms-387032 SCHEMBL20583046 | 0.89 | CDK2 (0.98) | CDK2CDK9CCNE2CCNE1CDK1 | |
| SCHEMBL20905302 | 0.89 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | CDK2 117/4885CDK9 147/4885CCNE2 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.