Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 1.00 |
| ▸ | CDK9 | P50750 | 13/20 | 1.00 |
| ▸ | CCNE2 | O96020 | 9/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 9/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.81 |
| ▸ | CDK1 | P06493 | 2/20 | 0.81 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.81 |
| ▸ | CDK7 | P50613 | 2/20 | 0.81 |
| ▸ | CCNH | P51946 | 2/20 | 0.81 |
| ▸ | CIT | O14578 | 1/20 | 0.81 |
| ▸ | CASK | O14936 | 1/20 | 0.81 |
| ▸ | AURKA | O14965 | 1/20 | 0.81 |
| ▸ | GAK | O14976 | 1/20 | 0.81 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.81 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.81 |
| ▸ | ULK1 | O75385 | 1/20 | 0.81 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.81 |
| ▸ | PAK3 | O75914 | 1/20 | 0.81 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.81 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730239 | 1.00 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| SCHEMBL4731289 | 1.00 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| Hydrochloric Acid SCHEMBL6183632 | 0.99 | CDK2 (0.98) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| Hydrochloric Acid SCHEMBL6183623 | 0.99 | CDK2 (0.98) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| Hydrochloric Acid SCHEMBL6183918 | 0.99 | CDK2 (0.98) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| SCHEMBL6911788 | 0.91 | CDK2 (0.83) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| SCHEMBL6911525 | 0.91 | CDK2 (0.83) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| Bms-387032 SCHEMBL187401 | 0.90 | CDK2 (1.00) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| SCHEMBL14067131 | 0.89 | CDK2 (0.82) | CDK2CDK9CCNE2CCNE1CCNT1 | |
| Bms-387032 SCHEMBL20583046 | 0.89 | CDK2 (0.98) | CDK2CDK9CCNE2CCNE1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188524-A1 | Methods of treating pain | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-08-07 | — | — | US | claimed |
| WO-2008049856-A2 | METHODS OF TREATING PAIN USING CDK INHIBITORS | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-05-02 | — | — | WO | claimed |
| EP-1568368-A1 | Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-08-31 | — | — | EP | claimed |
| EP-1240166-B1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-16 | — | — | EP | claimed |
| EP-1429764-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2004-06-23 | — | — | EP | claimed |
| US-20030114504-A1 | Compositions and methods for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-19 | — | — | US | claimed |
| EP-1303513-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL] CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | Bristol-Myers Squibb Company (US) | 2003-04-23 | — | — | EP | claimed |
| US-6534531-B2 | Thiazole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2003-03-18 | — | — | US | claimed |
| WO-2003020272-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-13 | — | — | WO | claimed |
| EP-1282419-A2 | METHODS FOR PREVENTING AND TREATING ALOPECIA INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-12 | — | — | EP | claimed |
| US-6515004-B1 | Useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-04 | — | — | US | claimed |
| EP-1240166-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-18 | — | — | EP | claimed |
| US-20020061915-A1 | Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy | BRISTOL-MYERS SQUIBB COMPANY | 2002-05-23 | — | — | US | claimed |
| WO-2002010162-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL] CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-02-07 | — | — | WO | claimed |
| WO-2001044242-A9 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2001-11-08 | — | — | WO | claimed |
| WO-2001080813-A2 | METHODS FOR PREVENTING AND TREATING ALOPECIA INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | claimed |
| WO-2001044242-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | claimed |
| US-20080188524-A1 | Methods of treating pain | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-08-07 | — | — | US | disclosed |
| WO-2001044242-A9 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2001044242-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188524-A1 | Methods of treating pain | CDK3, CDK1, CDK5 | CDK2 4/4885CDK9 18/4885CCNE2 84/4885 |
| US-20020061915-A1 | Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy | NR5A1, CYP17A1, CYP21A2 | CDK2 2778/4885CDK9 3861/4885CCNE2 1200/4885 |
| US-20030114504-A1 | Compositions and methods for the treatment of cancer | CDK4, CDK2, PLK1 | CDK2 2/4885CDK9 84/4885CCNE2 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.