Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771921 | 0.86 | SLC6A2 (0.36) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL19464253 | 0.80 | CHRNB2 (0.50) | OPRL1CYP2A6CHRNB2CHRNA4 | |
| SCHEMBL20851551 | 0.80 | CHRNB2 (0.50) | OPRL1CYP2A6CHRNB2CHRNA4 | |
| SCHEMBL30586977 | 0.79 | OPRL1 (0.43) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL2472323 | 0.79 | OPRL1 (0.43) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL2477395 | 0.79 | OPRL1 (0.40) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL2474725 | 0.79 | OPRL1 (0.40) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL2472847 | 0.79 | OPRL1 (0.43) | NOS3NOS1NOS2METAP2OPRL1 | |
| SCHEMBL21516009 | 0.79 | CHRNB2 (0.51) | OPRL1CYP2A6CHRNB2CHRNA4 | |
| SCHEMBL15237647 | 0.79 | CHRNB2 (0.51) | OPRL1CYP2A6CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |