Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216298 | 0.94 | HSD17B10 (0.51) | SIRT2SIRT1HSD17B10CYP3A4CNR2 | |
| SCHEMBL14067973 | 0.90 | CYP3A4 (0.56) | SIRT2SIRT1CYP3A4CNR2HRH1 | |
| SCHEMBL14067842 | 0.89 | HSD17B10 (0.57) | SIRT2SIRT1HSD17B10CYP3A4KDM4E | |
| SCHEMBL14067969 | 0.87 | KDM4E (0.53) | SIRT2SIRT1CNR2HTR2AHTR2C | |
| SCHEMBL10154872 | 0.83 | HSD17B10 (0.61) | SIRT2SIRT1HSD17B10KDM4EPTGDR2 | |
| SCHEMBL16140207 | 0.82 | SIRT2 (0.59) | SIRT2SIRT1HSD17B10CYP3A4HRH1 | |
| SCHEMBL3318769 | 0.82 | HTR6 (0.62) | SIRT2SIRT1HRH1HTR6ADRA2A | |
| SCHEMBL16140204 | 0.80 | SIRT2 (0.60) | SIRT2SIRT1HSD17B10CYP3A4HRH1 | |
| SCHEMBL10127820 | 0.80 | HRH1 (0.54) | SIRT2SIRT1HSD17B10CNR2HRH1 | |
| SCHEMBL1120682 | 0.80 | HRH1 (0.51) | HSD17B10CNR2HRH1HTR6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115098-A2 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2008-09-25 | — | — | WO | disclosed |