Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.55 |
| ▸ | PRKACA | P17612 | 6/20 | 0.55 |
| ▸ | PIM1 | P11309 | 3/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.55 |
| ▸ | AKT2 | P31751 | 3/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.55 |
| ▸ | GSK3A | P49840 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.55 |
| ▸ | CHUK | O15111 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 4/20 | 0.53 |
| ▸ | PRKACB | P22694 | 4/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14068385 | 0.92 | AKT1 (0.62) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL14004896 | 0.85 | AKT1 (0.52) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL14068430 | 0.83 | AKT1 (0.49) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL13535014 | 0.82 | PDGFRB (0.49) | MAPK1 | |
| Hydrochloric Acid SCHEMBL6835588 | 0.80 | AKT1 (0.84) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL6853479 | 0.79 | AKT1 (0.67) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL14030021 | 0.78 | AKT1 (0.61) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL14030029 | 0.78 | AKT1 (0.61) | AKT1PRKACAPIM1RPS6KB1AKT2 | |
| SCHEMBL7258949 | 0.77 | LTA4H (0.68) | LTA4H | |
| SCHEMBL14004889 | 0.76 | AKT1 (0.59) | AKT1PRKACAPIM1RPS6KB1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |