Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14068804 | 0.90 | RXFP1 (0.86) | RXFP1KDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL13496444 | 0.77 | RXFP1 (0.68) | RXFP1KDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL13496432 | 0.73 | KDM4E (0.80) | RXFP1KDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL13496399 | 0.72 | KDM4E (0.80) | RXFP1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL12594562 | 0.70 | ALOX15 (0.75) | RXFP1KDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL12594566 | 0.70 | ALOX15 (0.72) | RXFP1KDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL13496425 | 0.70 | KDM4E (0.84) | RXFP1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL13561457 | 0.70 | ALOX15 (0.74) | RXFP1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL13496422 | 0.69 | ALOX15 (1.00) | KDM4EHSD17B10SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14068783 | 0.69 | KDM4E (0.68) | KDM4EHSD17B10SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |