Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.58 |
| ▸ | AXL | P30530 | 5/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | FLT3 | P36888 | 13/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | MERTK | Q12866 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614569 | 0.92 | MET (0.59) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL2098431 | 0.92 | FLT3 (0.67) | METAXLKDRFLT3PDGFRA | |
| SCHEMBL469293 | 0.84 | MET (0.75) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL469347 | 0.83 | MET (0.84) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL2099171 | 0.83 | FLT3 (0.65) | METAXLKDRFLT3PDGFRA | |
| SCHEMBL2614571 | 0.83 | MET (0.63) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL469294 | 0.82 | MET (0.75) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL469252 | 0.82 | MET (0.75) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL14069023 | 0.82 | MET (0.47) | METAXLKDRFLT3PDGFRB | |
| SCHEMBL6376965 | 0.81 | FLT3 (0.79) | METAXLKDRFLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112408-A1 | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2008-09-18 | — | — | WO | disclosed |