Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.55 |
| ▸ | GNG2 | P59768 | 5/20 | 0.54 |
| ▸ | GNB1 | P62873 | 5/20 | 0.54 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CHAT | P28329 | 4/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.48 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069687 | 0.93 | PHLPP2 (0.57) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL1592192 | 0.81 | PHLPP2 (0.67) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL12172884 | 0.81 | GNG2 (0.61) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL18493688 | 0.80 | GNG2 (0.60) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL1592676 | 0.80 | PHLPP2 (0.62) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL11781902 | 0.80 | PHLPP2 (0.65) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL8972954 | 0.79 | PHLPP2 (0.63) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL13214010 | 0.78 | GNG2 (0.78) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL11321111 | 0.77 | GNG2 (0.81) | PHLPP2GNG2GNB1HPGDSCYP1A2 | |
| SCHEMBL3019530 | 0.77 | GNG2 (0.77) | PHLPP2GNG2GNB1HPGDSCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107211-A2 | NOVEL P2Y12 RECEPTOR ANTAGONISTS | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN (DE) | 2008-09-12 | — | — | WO | disclosed |