Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.67 |
| ▸ | LCK | P06239 | 10/20 | 0.58 |
| ▸ | KDR | P35968 | 7/20 | 0.58 |
| ▸ | SRC | P12931 | 7/20 | 0.58 |
| ▸ | LYN | P07948 | 5/20 | 0.58 |
| ▸ | INSR | P06213 | 4/20 | 0.58 |
| ▸ | HCK | P08631 | 4/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.57 |
| ▸ | BRAF | P15056 | 5/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070187 | 0.96 | BTK (0.66) | BTKLCKKDRSRCLYN | |
| SCHEMBL14069862 | 0.94 | BTK (0.60) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070167 | 0.93 | LCK (0.68) | BTKLCKKDRSRCLYN | |
| SCHEMBL14069856 | 0.91 | LCK (0.66) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070195 | 0.89 | BTK (0.69) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070183 | 0.89 | LCK (0.68) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070186 | 0.89 | BTK (0.68) | BTKLCKKDRSRCLYN | |
| SCHEMBL14069836 | 0.88 | BTK (0.67) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070253 | 0.88 | LCK (0.69) | BTKLCKKDRSRCLYN | |
| SCHEMBL14070184 | 0.88 | BTK (0.66) | BTKLCKKDRSRCLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |