Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.69 |
| ▸ | KDR | P35968 | 6/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.65 |
| ▸ | BTK | Q06187 | 5/20 | 0.65 |
| ▸ | SRC | P12931 | 4/20 | 0.65 |
| ▸ | TYK2 | P29597 | 2/20 | 0.65 |
| ▸ | SYK | P43405 | 2/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | INSR | P06213 | 3/20 | 0.54 |
| ▸ | LYN | P07948 | 3/20 | 0.54 |
| ▸ | HCK | P08631 | 3/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.54 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.54 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.54 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.54 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070209 | 0.96 | LCK (0.64) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070167 | 0.95 | LCK (0.68) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14069862 | 0.93 | BTK (0.60) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070183 | 0.91 | LCK (0.68) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14069856 | 0.89 | LCK (0.66) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070271 | 0.88 | BTK (0.61) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070163 | 0.88 | BTK (0.67) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070277 | 0.88 | BTK (0.60) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070248 | 0.87 | BTK (0.60) | LCKKDRMAPK14BTKSRC | |
| SCHEMBL14070282 | 0.87 | BTK (0.60) | LCKKDRMAPK14BTKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |