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SCHEMBL14070218

SCHEMBL14070218

Cc1ccc(NC(=O)c2cc(OC3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1nn(C)c2nc(NCCCCN(C)C)ncc12

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 2/20 0.53
▸ LCK P06239 3/20 0.51
▸ INSR P06213 2/20 0.51
▸ LYN P07948 2/20 0.51
▸ HCK P08631 2/20 0.51
▸ SRC P12931 2/20 0.51
▸ KDR P35968 2/20 0.51
▸ BTK Q06187 3/20 0.50
▸ BRAF P15056 12/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14070219 0.89 BTK (0.56) LCKINSRLYNHCKSRC
SCHEMBL14070189 0.85 BTK (0.65) CSF1RLCKINSRLYNHCK
SCHEMBL14070080 0.83 BRAF (0.56) CSF1RLCKINSRLYNHCK
SCHEMBL14070214 0.83 BRAF (0.56) CSF1RLCKINSRLYNHCK
SCHEMBL14069576 0.82 CSF1R (0.51) CSF1RLCKINSRLYNHCK
SCHEMBL14069750 0.82 BTK (0.53) LCKINSRLYNHCKSRC
SCHEMBL14069575 0.82 BTK (0.48) LCKINSRLYNHCKSRC
SCHEMBL14069749 0.82 BTK (0.53) LCKINSRLYNHCKSRC
SCHEMBL14069863 0.81 BTK (0.58) LCKINSRLYNHCKSRC
SCHEMBL14070065 0.80 BRAF (0.60) LCKINSRLYNHCKSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008112695-A2 PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT IRM LLC (BM) 2008-09-18 — — WO disclosed
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