Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.73 |
| ▸ | BRAF | P15056 | 9/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.54 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.54 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.54 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.54 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.54 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.54 |
| ▸ | AGPS | O00116 | 1/20 | 0.54 |
| ▸ | MYO1F | O00160 | 1/20 | 0.54 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.54 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.54 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069733 | 0.91 | BTK (0.74) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070193 | 0.90 | BTK (0.75) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070255 | 0.89 | BTK (0.73) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070166 | 0.88 | BTK (0.70) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070246 | 0.88 | BTK (0.72) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14069588 | 0.87 | BTK (0.67) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL20558521 | 0.87 | BTK (0.67) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070195 | 0.87 | BTK (0.69) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070182 | 0.87 | BTK (0.70) | BTKBRAFMAPK14ABL1SRC | |
| SCHEMBL14070186 | 0.87 | BTK (0.68) | BTKBRAFMAPK14ABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |