Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.67 |
| ▸ | KIT | P10721 | 3/20 | 0.65 |
| ▸ | CSF1R | P07333 | 3/20 | 0.65 |
| ▸ | LCK | P06239 | 4/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.58 |
| ▸ | BRAF | P15056 | 11/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.56 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20558521 | 0.90 | BTK (0.67) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070288 | 0.89 | BTK (0.55) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14069733 | 0.89 | BTK (0.74) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070272 | 0.89 | BTK (0.54) | BTKKITCSF1RLCKKDR | |
| SCHEMBL4787917 | 0.89 | BTK (0.66) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070193 | 0.88 | BTK (0.75) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070273 | 0.87 | BTK (0.52) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070254 | 0.87 | BTK (0.73) | BTKKITCSF1RLCKKDR | |
| SCHEMBL4785228 | 0.87 | BTK (0.64) | BTKKITCSF1RLCKKDR | |
| SCHEMBL14070195 | 0.87 | BTK (0.69) | BTKKITCSF1RLCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |