Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063574 | 0.83 | MAPK14 (0.38) | MAPK14F9TNKS2BRD4LCK | |
| SCHEMBL14072375 | 0.76 | JAK2 (0.55) | — | |
| SCHEMBL24427249 | 0.75 | F9 (0.41) | MAPK14F9LCKCSF1RDYRK1A | |
| SCHEMBL14072365 | 0.74 | MAP4K4 (0.52) | MAPK14F9DYRK1A | |
| SCHEMBL13376464 | 0.74 | MAP4K4 (0.58) | MAPK14F9LCKCSF1RDYRK1A | |
| SCHEMBL7072970 | 0.73 | MAP4K4 (0.46) | MAPK14F9LCKCSF1RDYRK1A | |
| SCHEMBL4804556 | 0.73 | F11 (0.43) | MAPK14 | |
| SCHEMBL13525173 | 0.72 | MAPK14 (0.45) | MAPK14F9LCKCSF1RDYRK1A | |
| SCHEMBL24427252 | 0.72 | F9 (0.41) | MAPK14F9LCKCSF1RDYRK1A | |
| SCHEMBL4804544 | 0.72 | F11 (0.34) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |