Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.86 |
| ▸ | RPA1 | P27694 | 2/20 | 0.74 |
| ▸ | GFER | P55789 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NPY2R | P49146 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870887 | 0.90 | MEN1 (0.82) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870878 | 0.86 | MEN1 (0.88) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870884 | 0.86 | MEN1 (0.88) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870881 | 0.85 | MEN1 (0.86) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870868 | 0.85 | RPA1 (1.00) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870863 | 0.84 | MEN1 (1.00) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL14292254 | 0.83 | MAPT (0.76) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL13870883 | 0.81 | MEN1 (0.81) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL14075285 | 0.81 | RAD52 (0.76) | MEN1KMT2ARPA1GFERNPC1 | |
| SCHEMBL4094983 | 0.80 | MEN1 (0.66) | MEN1KMT2AMAPTPTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |