Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14090338 | 0.85 | APP (0.47) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL14076009 | 0.83 | APP (0.45) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL15080535 | 0.83 | APP (0.57) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL14075998 | 0.81 | APP (0.58) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL9133017 | 0.79 | APP (0.65) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL14076008 | 0.78 | APP (0.62) | APPRAB9ASHBG | |
| SCHEMBL25470835 | 0.78 | APP (0.52) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL14090337 | 0.77 | PAX8 (0.43) | APPL3MBTL1APAF1USP2RAB9A | |
| SCHEMBL4985743 | 0.77 | APP (1.00) | APPL3MBTL1RAB9ATNKSQPCT | |
| SCHEMBL1809125 | 0.74 | APP (1.00) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44354-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-09 | — | — | US | disclosed |
| US-RE44354-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-09 | — | — | US | disclosed |
| US-RE44338-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-RE44338-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | APP 1/4885L3MBTL1 1784/4885APAF1 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.