Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272169 | 0.83 | CYP1A2 (0.61) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL5273528 | 0.83 | CYP1A2 (0.61) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL4343686 | 0.83 | CYP1A2 (0.61) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL6693143 | 0.82 | ESR1 (0.53) | LDHATDP1RAB9AMEN1KMT2A | |
| SCHEMBL11716060 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL28871353 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL5277876 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL6696803 | 0.80 | LDHA (0.49) | LDHASMN1; SMN2MAPTTDP1MEN1 | |
| SCHEMBL8935640 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 | |
| SCHEMBL8935642 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTTDP1L3MBTL1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080220536-A1 | Methods for Identifying Compounds that Modulate Enzymatic Activities by Employing Covalently Bonded Target-Extender Complexes with Ligand Candidates | ERIANSON DANIEL A | 2008-09-11 | — | — | US | disclosed |
| US-20080220536-A1 | Methods for Identifying Compounds that Modulate Enzymatic Activities by Employing Covalently Bonded Target-Extender Complexes with Ligand Candidates | ERIANSON DANIEL A | 2008-09-11 | — | — | US | disclosed |
| US-7214487-B2 | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214487-B2 | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-05-08 | — | — | US | disclosed |