Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861597 | 0.80 | NR1H2 (0.46) | ALDH1A1HPGDMAPTNPSR1KDM4E | |
| SCHEMBL1407814 | 0.72 | NR1H2 (0.51) | ALDH1A1HPGDMAPTNPSR1KDM4E | |
| SCHEMBL1407440 | 0.71 | NR1H2 (0.45) | ALDH1A1LMNAMAPK1NR1H2NR1H3 | |
| SCHEMBL5244461 | 0.70 | ITGB2 (0.40) | NR1H2NR1H3NR1I2NR3C1SOS1 | |
| SCHEMBL31067148 | 0.66 | SLC6A2 (0.50) | ALDH1A1HPGDMAPTNPSR1KDM4E | |
| SCHEMBL1407879 | 0.65 | NR1H2 (0.54) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27730583 | 0.64 | NR1H2 (0.47) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407980 | 0.64 | NR1H2 (0.48) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407366 | 0.64 | NR1H2 (0.50) | ALDH1A1LMNANR1H2NR1H3NR1I2 | |
| SCHEMBL3857590 | 0.64 | NR1H2 (0.44) | ALDH1A1NR1H2NR1H3NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295429-A1 | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |