Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407884 | 0.70 | ROCK2 (0.44) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL5246499 | 0.69 | NR1H2 (0.35) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL4030919 | 0.69 | NR1H2 (0.46) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL5348609 | 0.68 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL5283390 | 0.68 | SOS1 (0.43) | NR1H2NR1H3NR1I2NR3C1HSD11B1 | |
| SCHEMBL5247686 | 0.66 | NR1H2 (0.61) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407219 | 0.65 | NR1H3 (1.00) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407613 | 0.65 | NR1H2 (0.72) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407211 | 0.65 | NR1H2 (0.90) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407161 | 0.65 | NR1H2 (0.77) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | claimed |
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | disclosed |