Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389368 | 0.87 | PKM (0.68) | PKMPOLBADRA2AADRA2BADRA2C | |
| SCHEMBL14079210 | 0.85 | PKM (0.47) | PKMPOLBHRH3MEN1KMT2A | |
| SCHEMBL23634077 | 0.83 | PKM (0.74) | PKMPOLBADRA2AADRA2BADRA2C | |
| SCHEMBL14079213 | 0.83 | PKM (0.45) | PKMPOLBCYP1A2GAAHRH3 | |
| SCHEMBL4672947 | 0.78 | PKM (0.67) | PKMPOLBADRA2AADRA2BADRA2C | |
| SCHEMBL2790806 | 0.78 | PKM (0.67) | PKMPOLBADRA2AADRA2BADRA2C | |
| SCHEMBL16706322 | 0.76 | PKM (0.68) | PKMPOLBADRA2AADRA2BADRA2C | |
| SCHEMBL14079204 | 0.76 | PKM (0.61) | PKMPOLBCYP1A2GAANPC1 | |
| SCHEMBL14659505 | 0.73 | PKM (0.64) | PKMPOLBNPC1MEN1RAB9A | |
| SCHEMBL2790502 | 0.73 | PKM (0.64) | PKMPOLBADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425557-B2 | Inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-16 | — | — | US | disclosed |