Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | F3 | P13726 | 1/20 | 0.51 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL19057040 | 1.00 | F7 (0.51) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL15699 | 0.95 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL22748483 | 0.95 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL2564207 | 0.95 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL23859925 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL7712105 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL22129922 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL28614873 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL23531099 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL11807677 | 0.94 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337625-B1 | STEM CELLS, METHOD FOR EXPANSION IN VITRO AND USE THEREOF | SCHELLER ALBERT (DE) | 2004-07-14 | — | — | EP | claimed |
| US-6642031-B2 | Pseudomonas microorganism for use in the generation of indigo | GENENCOR INTERNATIONAL, INC. | 2003-11-04 | — | — | US | claimed |
| JP-8231404-A | — | — | None | — | — | JP | disclosed |
| WO-2023143356-A1 | METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR FOR TREATING MTAP DELETION-TYPE CANCER | 勤浩医药（苏州）有限公司 | 2023-08-03 | — | — | WO | disclosed |
| US-11629340-B2 | DHFR tunable protein regulation | OBSIDIAN THERAPEUTICS, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| US-20230092895-A1 | TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS, INC. | 2023-03-23 | — | — | US | disclosed |
| US-20230089537-A1 | DIETARY SUPPLEMENT AND METHOD FOR SYNTHESIS OF SAME | StrongCell LLC | 2023-03-23 | — | — | US | disclosed |
| US-20230091651-A1 | DIETARY SUPPLEMENT AND METHOD FOR SYNTHESIS OF SAME | StrongCell LLC | 2023-03-23 | — | — | US | disclosed |
| US-20220213449-A1 | DHFR TUNABLE PROTEIN REGULATION | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | US | disclosed |
| US-20220175781-A1 | CD40L COMPOSITIONS AND METHODS FOR TUNABLE REGULATION | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-06-09 | — | — | US | disclosed |
| CN-114480563-A | Composition and kit for detecting adenosine deaminase activity | 广州达安基因股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| EP-0932662-A1 | MICROORGANISMS WITH ABILITY TO DEGRADE INDOLE AND ENZYMES THEREFROM | GENENCOR INTERNATIONAL, INC. (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0872244-A1 | Cosmetic or pharmaceutical composition containing an Andiroba extract | LABORATOIRES DE BIOLOGIE VEGETALE YVES ROCHER (FR) | 1998-10-21 | — | — | EP | disclosed |
| US-5750512-A | FOR TREATMENT OF PARKINSON'S AND ALZHEIMER'S DISEASE OR MENTAL DEPRESSION | BIRKMAYER PHARMACEUTICALS, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1998013474-A1 | MICROORGANISMS WITH ABILITY TO DEGRADE INDOLE AND ENZYMES THEREFROM | GENENCOR INTERNATIONAL, INC. (US) | 1998-04-02 | — | — | WO | disclosed |
| US-5654288-A | OXIDATION RESISTANCE | BIRKMAYER PHARMACEUTICALS, INC. (US) | 1997-08-05 | — | — | US | disclosed |
| JP-H08231404-A | NADH AND NADPH THERAPEUTIC AGENT FOR NASAL, SUBLINGUAL, RECTAL AND DERMAL ADMINISTRATION | BIRKMAYER USA | 1996-09-10 | — | — | JP | disclosed |
| EP-0722734-A1 | NADH and NADPH therapeutic agents for nasal, sublingual, rectal and dermal administration | BIRKMAYER U.S.A. (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5508179-A | INCUBATING MIXTURE OF NAD, NUCLEIC ACID OLIGONUCLEOTIDES AND A NAH DINUCLEOTIDE-DEPENDENT NUCLEIC ACID LIGASE; | BIO-RAD LABORATORIES, INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5019561-A | Treatment of Parkinson's disease with NADPH | BIRKMAYER JOERG (AT) | 1991-05-28 | — | — | US | disclosed |