Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680295 | 0.75 | HPGD (0.41) | HPGDKMT2AMAPTMEN1RAB9A | |
| SCHEMBL28420979 | 0.72 | POLB (0.36) | HPGDKMT2AMAPTMEN1RAB9A | |
| SCHEMBL30576990 | 0.72 | POLB (0.36) | HPGDKMT2AMAPTMEN1RAB9A | |
| SCHEMBL28435916 | 0.72 | ABCB1 (0.37) | HPGDKMT2AMAPTMEN1RAB9A | |
| Phosphine SCHEMBL1505614 | 0.72 | POLB (0.34) | HPGDKMT2AMAPTMEN1RAB9A | |
| SCHEMBL28435918 | 0.72 | ABCB1 (0.37) | HPGDKMT2AMAPTMEN1RAB9A | |
| SCHEMBL28457190 | 0.70 | AKT2 (0.48) | HPGDKMT2AMAPTRAB9ANPSR1 | |
| SCHEMBL27400436 | 0.70 | BRD4 (0.44) | HPGDKMT2AMAPTRAB9ANPSR1 | |
| SCHEMBL12815311 | 0.70 | HPGD (0.35) | HPGDKMT2AMAPTMEN1RAB9A | |
| Phosphine SCHEMBL5609398 | 0.70 | MEN1 (0.36) | HPGDKMT2AMAPTMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295429-A1 | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |