Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137055 | 0.93 | POLB (0.43) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4131381 | 0.88 | POLB (0.43) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4136250 | 0.85 | POLB (0.42) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4139196 | 0.85 | POLB (0.42) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL11946250 | 0.85 | CXCR3 (0.38) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4147841 | 0.84 | POLB (0.45) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4131223 | 0.83 | POLB (0.41) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL4131204 | 0.83 | POLB (0.41) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL11945656 | 0.83 | POLB (0.42) | MAPTALDH1A1LMNACYP2C19POLB | |
| SCHEMBL11944363 | 0.83 | POLB (0.46) | MAPTALDH1A1LMNACYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |