Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943344 | 0.94 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943397 | 0.89 | BCL2L1 (0.48) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943345 | 0.84 | NPC1 (0.43) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943368 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2LMNAPOLBKMT2AMAPT | |
| SCHEMBL11943340 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943432 | 0.80 | CYP2D6 (0.48) | SMN1; SMN2LMNAKMT2ADRD2DRD3 | |
| SCHEMBL11943422 | 0.80 | MAPK14 (0.45) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943429 | 0.80 | SMO (0.48) | LMNAPOLBKMT2AMAPTDRD4 | |
| SCHEMBL11943360 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2LMNAPOLBKMT2AMAPT | |
| SCHEMBL11943472 | 0.79 | DRD4 (0.51) | SMN1; SMN2LMNAPOLBKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |