Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.68 |
| ▸ | PIM1 | P11309 | 3/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7558738 | 0.87 | CA2 (0.71) | GSK3BNPC1RAB9AHPGDLMNA | |
| SCHEMBL4801244 | 0.87 | CA2 (0.71) | GSK3BNPC1RAB9AHPGDLMNA | |
| SCHEMBL4806036 | 0.87 | CA2 (0.71) | GSK3BNPC1RAB9AHPGDLMNA | |
| SCHEMBL15091371 | 0.85 | GSK3B (0.70) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL15101838 | 0.85 | GSK3B (0.70) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL2541079 | 0.84 | PIM1 (0.69) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL2541077 | 0.84 | PIM1 (0.69) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL1248964 | 0.82 | CA2 (0.76) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL1248963 | 0.82 | CA2 (0.76) | GSK3BPIM1PIM2AKR1B1NPC1 | |
| SCHEMBL15421728 | 0.82 | CA2 (0.76) | GSK3BPIM1PIM2AKR1B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417064-B2 | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake | ELI LILLY AND COMPANY (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417064-B2 | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake | ELI LILLY AND COMPANY (US) | 2008-08-26 | — | — | US | disclosed |