Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414433 | 0.86 | MAPT (0.62) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL25432578 | 0.79 | MAPT (0.58) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL1408528 | 0.77 | LMNA (0.54) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL1408703 | 0.77 | MAPT (0.53) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL15954532 | 0.76 | MAPT (0.56) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL1408345 | 0.76 | MAPT (0.58) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL10815946 | 0.75 | MAPT (0.68) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL20603943 | 0.74 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL7037530 | 0.74 | MAPK13 (0.72) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL6802809 | 0.74 | MAPT (0.56) | MAPTNPC1RAB9AMAPK1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874770-B1 | PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-09 | — | — | EP | disclosed |