Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 11/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084890 | 0.97 | BDKRB1 (0.52) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084891 | 0.91 | BDKRB1 (0.47) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084914 | 0.90 | BDKRB1 (0.47) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084907 | 0.89 | BDKRB1 (0.46) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084923 | 0.88 | KDM2B (0.48) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL4704306 | 0.88 | BDKRB1 (0.45) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084845 | 0.88 | BDKRB1 (0.57) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL4703545 | 0.88 | RAB9A (0.50) | BDKRB1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL14084911 | 0.86 | KDM5A (0.47) | BDKRB1KDM5ACCNA2CDK2CCNA1 | |
| SCHEMBL14084974 | 0.85 | BDKRB1 (0.53) | BDKRB1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |