Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.57 |
| ▸ | PGR | P06401 | 4/20 | 0.57 |
| ▸ | ESR1 | P03372 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086075 | 0.91 | NR3C1 (0.54) | NR3C1PGRESR1ARMEN1 | |
| SCHEMBL14111302 | 0.84 | NR3C1 (0.41) | NR3C1PGRESR1ARMEN1 | |
| SCHEMBL14086067 | 0.82 | NR3C1 (0.66) | NR3C1PGRESR1ARALDH1A1 | |
| SCHEMBL14086083 | 0.82 | NR3C1 (0.58) | NR3C1PGRESR1ARMAPT | |
| SCHEMBL14196989 | 0.81 | NR3C1 (0.55) | NR3C1PGRESR1AR | |
| SCHEMBL12864651 | 0.77 | NR3C1 (0.53) | NR3C1PGRESR1AR | |
| SCHEMBL12305202 | 0.77 | NR3C1 (0.59) | NR3C1PGRESR1AR | |
| SCHEMBL14111309 | 0.75 | NR3C1 (0.39) | NR3C1PGRESR1ARMEN1 | |
| SCHEMBL11961415 | 0.75 | NR3C1 (0.48) | NR3C1PGRESR1ARMAPT | |
| SCHEMBL12306769 | 0.75 | NR3C1 (0.56) | NR3C1PGRESR1ARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411071-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411071-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-12 | — | — | US | disclosed |