⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197212 | 0.83 | KDM4E (0.53) | — | |
| SCHEMBL21610450 | 0.79 | — | — | |
| SCHEMBL20197181 | 0.78 | HDAC8 (0.37) | — | |
| SCHEMBL3184879 | 0.78 | MAPT (0.36) | — | |
| SCHEMBL20197182 | 0.78 | KCNH2 (0.44) | — | |
| SCHEMBL4864193 | 0.77 | — | — | |
| SCHEMBL2983577 | 0.77 | — | — | |
| SCHEMBL4265097 | 0.77 | — | — | |
| SCHEMBL26555555 | 0.77 | — | — | |
| SCHEMBL19313522 | 0.77 | HDAC8 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210315872-A1 | COMPOUNDS AND METHODS FOR EP300 or CBP MODULATION AND INDICATIONS THEREFOR | Opna Bio SA (CH) | 2021-10-14 | — | — | US | disclosed |
| EP-2794611-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2017-10-11 | — | — | EP | disclosed |
| WO-2017101851-A1 | ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS | UNITY BIOTECHNOLOGY, INC. (US) | 2017-06-22 | — | — | WO | disclosed |
| US-7414036-B2 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2008-08-19 | — | — | US | disclosed |
| US-7414036-B2 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2008-08-19 | — | — | US | disclosed |