⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21610450 | 0.79 | — | — | |
| SCHEMBL4864193 | 0.77 | — | — | |
| SCHEMBL4265097 | 0.77 | — | — | |
| SCHEMBL14086544 | 0.77 | — | — | |
| SCHEMBL17911800 | 0.76 | TRPA1 (0.36) | — | |
| SCHEMBL15160638 | 0.76 | HDAC8 (0.39) | — | |
| SCHEMBL29898951 | 0.74 | — | — | |
| SCHEMBL2299751 | 0.74 | — | — | |
| SCHEMBL20197212 | 0.74 | KDM4E (0.53) | — | |
| SCHEMBL20197181 | 0.74 | HDAC8 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-B1 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH LLC (US) | 2015-11-18 | — | — | EP | disclosed |
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| EP-2029543-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-03-04 | — | — | EP | disclosed |
| US-7414036-B2 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2008-08-19 | — | — | US | disclosed |
| US-7414036-B2 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2008-08-19 | — | — | US | disclosed |
| US-7414036-B2 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2008-08-19 | — | — | US | disclosed |
| WO-2007146376-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
| US-20050101551-A1 | Compounds useful as A3 adenosine receptor agonists | MUSCAGEN LIMITED (GB) | 2005-05-12 | — | — | US | disclosed |
| WO-2005012323-A2 | COMPOUNDS USEFUL AS A3 ADENOSINE RECEPTOR AGONISTS | TRIGEN LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| EP-1469864-A1 | COMPOUNDS USEFUL AS A-3 ADENOSINE RECEPTOR AGONISTS | MUSCAGEN LIMITED (GB) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003061670-A1 | COMPOUNDS USEFUL AS A3 ADENOSINE RECEPTOR AGONISTS | MUSCAGEN LIMITED (GB) | 2003-07-31 | — | — | WO | disclosed |