SCHEMBL1408718

SCHEMBL1408718

NCCNS(=O)(=O)NCCO

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.40
CA12 O43570 4/20 0.37
CA14 Q9ULX7 4/20 0.37
CA2 P00918 3/20 0.37
CA7 P43166 2/20 0.37
CYP3A4 P08684 3/20 0.36
ALDH1A1 P00352 5/20 0.33
CYP2C19 P33261 5/20 0.33
TSHR P16473 1/20 0.33
GAA P10253 1/20 0.32
PKM P14618 1/20 0.32
PPARA Q07869 2/20 0.32
CYP2C9 P11712 2/20 0.32
HSD17B10 Q99714 2/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
LMNA P02545 1/20 0.31
SLC6A6 P31641 1/20 0.31
BLM P54132 1/20 0.31
MEN1 O00255 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1145734 0.87 CA1 (0.50) CA1CA12CA14CA2CA7
SCHEMBL27806975 0.75 CA1 (0.52) CA1CA12CA14CA2CA7
SCHEMBL1408713 0.73 CYP2C19 (0.40) ALDH1A1CYP2C19TSHRGAAPKM
SCHEMBL27015945 0.73 RELA (0.37) CA2CYP3A4ALDH1A1CYP2C19TSHR
SCHEMBL12765363 0.72
SCHEMBL29014370 0.72
SCHEMBL3879124 0.71 CA12 (0.34) CA1CA12CA14CA2CA7
SCHEMBL1012552 0.70
SCHEMBL360351 0.70
SCHEMBL12856657 0.70 CA1 (0.55) CA1CA12CA14CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022011211-A1 DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (US) 2022-01-13 WO disclosed
EP-1806378-B1 Polythiourethane UBE INDUSTRIES (JP) 2011-10-12 EP disclosed
EP-1743912-B1 POLYTHIOURETHANE UBE INDUSTRIES (JP) 2011-03-09 EP disclosed
US-7544761-B2 Polythiourethane UBE INDUSTRIES, LTD. (JP) 2009-06-09 US disclosed
US-7385022-B2 Polythiocarbonate polythiol UBE INDUSTRIES, LTD. (JP) 2008-06-10 US disclosed
US-20080058477-A1 having a high refractive index and low dispersion which is obtained through a reaction between a polythiol component containing one or more polythiocarbonate polythiol and a polyisocyanate component containing a polyisocyanate and/or a polyisothiocyanate UBE INDUSTRIES, LTD. A CORPORATION 1978-96 (JP) 2008-03-06 US disclosed
EP-1806378-A2 Polythiourethane Ube Industries, Ltd. (JP) 2007-07-11 EP disclosed
US-20070129530-A1 Polythiocarbonate polythiol UBE INDUSTRIES, LTD. A CORPORATION OF JAPAN (JP) 2007-06-07 US disclosed
EP-1743912-A1 POLYTHIOURETHANE Ube Industries, Ltd. (JP) 2007-01-17 EP disclosed