Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14091142 | 0.85 | ACKR3 (0.44) | ACKR3CYP3A4CYP2D6 | |
| SCHEMBL8230868 | 0.85 | ACKR3 (0.46) | ACKR3 | |
| SCHEMBL13391102 | 0.84 | ACKR3 (0.51) | ACKR3 | |
| SCHEMBL13591170 | 0.84 | CYP3A4 (0.52) | CYP3A4 | |
| SCHEMBL13003253 | 0.82 | GSK3B (0.45) | ACKR3 | |
| SCHEMBL13003276 | 0.80 | ACKR3 (0.44) | ACKR3CYP3A4CYP2D6 | |
| SCHEMBL8418718 | 0.79 | ACKR3 (0.55) | ACKR3CYP3A4CYP2D6 | |
| SCHEMBL13319053 | 0.78 | ALDH1A1 (0.54) | — | |
| SCHEMBL13003272 | 0.78 | MAPK1 (0.47) | ACKR3 | |
| SCHEMBL13319465 | 0.77 | ACKR3 (0.46) | ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408066-B2 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists | SCHERING CORPROATION (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070010513-A1 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists | SCHERING CORPORATION | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010513-A1 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists | HRH3, HRH4, CHRM1 | ACKR3 106/4885CYP3A4 907/4885CYP2D6 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.