Pyruvate

Pyruvate

SCHEMBL1409133

CC(=O)C(=O)O.O=CC(O)COP(=O)(O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MPI P34949 1/20 0.50
PGK1 P00558 1/20 0.48
PGK2 P07205 1/20 0.48
PGD P52209 4/20 0.46
LPAR1 Q92633 7/20 0.39
LPAR4 Q99677 3/20 0.39
LPAR5 Q9H1C0 3/20 0.39
LPAR2 Q9HBW0 3/20 0.39
LPAR3 Q9UBY5 3/20 0.39
ENPP2 Q13822 3/20 0.39
LPAR6 P43657 2/20 0.39
CES2 O00748 1/20 0.37
TRPV1 Q8NER1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28125367 0.87 MPI (0.63) MPIPGK1PGK2PGDLPAR1
SCHEMBL328992 0.87 MPI (0.63) MPIPGK1PGK2PGDLPAR1
SCHEMBL10709491 0.87 MPI (0.63) MPIPGK1PGK2PGDLPAR1
SCHEMBL1395698 0.87 MPI (0.63) MPIPGK1PGK2PGDLPAR1
SCHEMBL34088 0.87 MPI (0.63) MPIPGK1PGK2PGDLPAR1
Phosphoric Acid SCHEMBL11331805 0.86 MPI (0.50) MPIPGK1PGK2PGDLPAR1
Phosphoric Acid SCHEMBL7132362 0.86 MPI (0.50) MPIPGK1PGK2PGDLPAR1
Phosphoric Acid SCHEMBL615772 0.86 MPI (0.50) MPIPGK1PGK2PGDLPAR1
Phosphoric Acid SCHEMBL17103808 0.85 MPI (0.61) MPIPGK1PGK2PGDLPAR1
Phosphoric Acid SCHEMBL6754811 0.85 MPI (0.61) MPIPGK1PGK2PGDLPAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110914441-B Improved process for producing isobutene from 3-methylcrotonic acid 环球生物能源公司 2024-06-28 CN disclosed
EP-3622080-B1 IMPROVED METHODS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID GLOBAL BIOENERGIES (FR) 2024-03-27 EP disclosed
CN-108779477-B Method for producing isobutene from 3-methylcrotonyl-CoA 环球生物能源公司 2022-12-13 CN disclosed
EP-3090043-B1 3-HYDROXYISOVALERATE (HIV) SYNTHASE VARIANTS GLOBAL BIOENERGIES (FR) 2022-02-02 EP disclosed
US-20210403956-A1 METHODS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID GLOBAL BIOENERGIES (FR) 2021-12-30 US disclosed
US-11124806-B2 Methods for producing isobutene from 3-methylcrotonic acid GLOBAL BIOENERGIES (FR) 2021-09-21 US disclosed
US-20210277425-A1 IMPROVED METHODS FOR PRODUCING lSOBUTENE FROM 3-METHYLCROTONIC ACID GLOBAL BIOENERGIES (FR) 2021-09-09 US disclosed
CN-107075536-B Process for producing 3-hydroxy-3-methylbutyric acid 环球生物能源公司 2021-07-02 CN disclosed
CN-107075530-B Method for producing isobutene from 3-methylcrotonyl-CoA 环球生物能源公司 2021-06-01 CN disclosed
US-10941423-B2 Method for the production of isoamyl alcohol GLOBAL BIOENERGIES (FR) 2021-03-09 US disclosed
WO-2015101493-A1 3-HYDROXYISOVALERATE (HIV) SYNTHASE VARIANTS GLOBAL BIOENERGIES (FR) 2015-07-09 WO disclosed
US-9017977-B2 Method for the enzymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-coa SCIENTIST OF FORTUNE S.A. (LU) 2015-04-28 US disclosed
EP-2478109-B1 Method for the enzymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA SCIENTIST OF FORTUNE SA (LU) 2015-04-01 EP disclosed
US-20120220001-A1 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-HYDROXY-S-METHYLBUTYRIC ACID FROM ACETONE AND ACETYL-COA SCIENTIST OF FORTUNE S.A. (LU) 2012-08-30 US disclosed
EP-2478109-A1 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-HYDROXY-S-METHYLBUTYRIC ACID FROM ACETONE AND ACETYL-COA Marlière, Philippe (BE) 2012-07-25 EP disclosed
WO-2011032934-A1 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-HYDROXY-S-METHYLBUTYRIC ACID FROM ACETONE AND ACETYL-COA MARLIERE PHILIPPE (FR) 2011-03-24 WO disclosed
EP-2295593-A1 Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA Marliere, Philippe (FR) 2011-03-16 EP disclosed
US-7286973-B1 Method of screening inhibitors of mevalonate-independent isoprenoid biosynthetic pathway THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2007-10-23 US disclosed
WO-2001083769-A9 CRYSTALLIZATION OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHESIS SALK INST FOR BIOLOGICAL STUDI (US) 2003-02-06 WO disclosed
WO-2001083769-A2 CRYSTALLIZATION OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHESIS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2001-11-08 WO disclosed